GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7327064 | 1 | rs6563389 | chr13:36777536 | SOHLH2 | chr13:36742347-36871992:- | -0.39 | -5.2 | 3.19E-7 | Economic and political preferences |
| BLCA | cis | rs568617 | 1 | rs656980 | chr11:65656282 | CTSW | chr11:65647284-65651212:+ | -0.6 | -9.06 | 6.99E-18 | Crohn's disease |
| BLCA | cis | rs568617 | 1 | rs656980 | chr11:65656282 | SNX32 | chr11:65601410-65621170:+ | 0.34 | 4.75 | 2.91E-6 | Crohn's disease |
| BLCA | cis | rs947583 | 1 | rs6570043 | chr6:136134098 | PDE7B | chr6:136172834-136516708:+ | 0.21 | 3.86 | 0.000135 | Phosphorus levels |
| BLCA | cis | rs6579245 | 1 | rs6579245 | chr20:34125271 | CPNE1 | chr20:34213968-34262539:- | -0.54 | -6.66 | 9.54E-11 | Cholesterol, total |
| BLCA | cis | rs7714584 | 1 | rs6579803 | chr5:150255559 | LOC134466 | chr5:150310000-150326146:- | 0.48 | 6.27 | 9.54E-10 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs6579804 | chr5:150255931 | LOC134466 | chr5:150310000-150326146:- | 0.48 | 6.27 | 9.54E-10 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs6579806 | chr5:150271084 | LOC134466 | chr5:150310000-150326146:- | 0.45 | 5.81 | 1.33E-8 | Crohn's disease |
| BLCA | cis | rs703842 | 1 | rs6581155 | chr12:58178162 | FAM119B | chr12:58166383-58176323:+ | 0.27 | 4.34 | 1.83E-5 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs6581155 | chr12:58178162 | TSFM | chr12:58176536-58191367:+ | -0.36 | -6.55 | 1.91E-10 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs6581155 | chr12:58178162 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.23 | -4.12 | 4.74E-5 | Multiple sclerosis |
| BLCA | cis | rs7112513 | 1 | rs6589575 | chr11:116733310 | PCSK7 | chr11:117075789-117102811:- | -0.44 | -5.68 | 2.73E-8 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs6589576 | chr11:116735788 | PCSK7 | chr11:117075789-117102811:- | 0.41 | 5.49 | 7.46E-8 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs6589589 | chr11:116932428 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -5.21 | 3.05E-7 | Protein quantitative trait loci |
| BLCA | cis | rs6598955 | 1 | rs6598955 | chr1:26619649 | ZNF593 | chr1:26496388-26497362:+ | 0.21 | 4.47 | 1.02E-5 | Obesity-related traits |